seit 2006


I. Vasiliauskaité-Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. Grison, T. Waltrich-Augusto, M. Fortier, F. Hoh, E.M. Saied, C. Arenz, S. Basu, C. Leyrat*, S. Granier*
"Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy"
Nat.Commun. 2018 9, 5437.

V. Živanovic, Z. Kochovski, C. Arenz, Y. Lu, and J. Kneipp*
"SERS and Cryo-EM Directly Reveal Different Liposome Structures During Interaction with Gold Nanoparticles"
J Phys Chem Lett 2018 accepted,DOI: 10.1021/acs.jpclett.8b03191.

Z. H. Mohamed, T. Soukka, C. Arenz, M. Schäferling*
"Five-, four- and three-dentate europium chelates for anion sensing and their applicability to enzymatic dephosphorylation reactions"
Chemistry Select 2018 3,12430-12439.

Z. H. Mohamed, C. Rhein, E. M. Saied, J. Kornhuber, C. Arenz*
"FRET probes for measuring sphingolipid metabolizing enzyme activity (Review)"
Chem. Phys. Lipids 2018 accepted,DOI: 10.1016/j.chemphyslip.2018.09.014

J. Ren, E. M. Saied, A. Zhong, J. Snider, C. Ruiz, C. Arenz, L. M. Obeid, G. D. Girnun, Y. A. Hannun *
"Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in sphingolipid pathway"
J. Lipid Res. 2018 accepted, DOI: 10.1194/jlr.M088195.

E. M. Saied, T. L.-S. Le, T. Hornemann and C.Arenz*
"Synthesis and Characterization of some Atypical Sphingoid Bases"
Bioorg Med Chem 2018 accepted, DOI: 10.1016/j.bmc.2018.06.031.

B. L. J. Poad*, A. T. Maccarone, H. Yu, T. W. Mitchell, E. M. Saied, C. Arenz, T. Hornemann, J. N. Bull, E. J. Bieske, S. J. Blanksby*
"Differential-mobility spectrometry of 1-deoxysphingosine isomers: new insights into the gas phase structures of ionized lipids"
Anal Chem 2018, 90, 5343–5351.

B.F. Straub et al. "Trendbericht Organische Chemie 2017"
Nachr Chem 2018, 65, 249-280.


K. Hinrichs, T. Shaykhutdinov, C. Kratz, F. Rösicke, C. Schöniger, C. Arenz, N.H. Nickel, J. Rappich
"Electrochemical Modification of Large Area Graphene and Characterization by Vibrational Spectroscopy"
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (Elsevier) 2017, DOI 10.1016/B978-0-12-409547-2.14194-0

V. Zivanovic, F. Madzharova, Z. Heiner, C. Arenz, J. Kneipp*
"Specific Interaction of Tricyclic Antidepressants With Gold and Silver Nanostructures as Revealed by Combined One and Two-Photon Vibrational Spectroscopy"
J. Phys. Chem. C 2017, 121 22958-22968.

I. Vasiliauskaité-Brooks, R. Sounier, P. Rochaix, G. Bellot, M. Fortier, F. Hoh, L. De Colibus, C. Bechara, E.M. Saied, C. Arenz, C. Leyrat*, S. Granier*
"Structural insights into adiponectin receptors suggest ceramidase activity"
Nature 2017, 544, 120-123.

L. Collenburg, N. Beyersdorf, C. Arenz, E. M. Saied, E. Avota, S. Schneider-Schaulies*
"The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration"
Front. Immunol. 2017, 8, 1007.

C. Arenz* "Recent advances and novel treatments for sphingolipidoses (Review)"
Future Med Chem 2017, 9, 1687-1700.

S. Koch-Edelmann, S. Banhart, E. M. Saied, L. Rose, L. Aeberhard, M. Laue, J. Doellinger, C. Arenz and D. Heuer*
"The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake"
Cell Microbiol 2017, 19, e12752, doi: 110.1111/cmi.12752.

M. McVey, M. Kim, A. Tabuchi, V. Srbely, L. Japtok, C. Arenz, O. Rotstein, B. Kleuser, J. Semple, W. Kuebler*
"Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets"
Am J Physiol Lung Cell Mol Physiol. 2017, 312, L625-L637

T. Pinkert, D. Furkert, T. Korte, A. Herrmann, C. Arenz*
"Lipid-Water Partition-Amplified FRET Probe for Life-Cell Detection of Acid Sphingomyelinase"
Angew. Chem. 2017, 129, 2834–2838.

B.F. Straub et al. "Trendbericht Organische Chemie 2016"
Nachr Chem 2017, 64, 266-304.

M. Sharar, E.M. Saied, M. Corte, C. Arenz, M. Linscheid, M. Montes-Bayón*
"Elemental Labelling and Mass Spectrometry for the Specific Detecion of Sulfenic Acid Groups in Model Peptides: A Proof of Concept"
Anal. Bioanal. Chem. 2017, 409, 2015-2027.

I. Alecu, A. Othman, A. Penno, E.M. Saied, C. Arenz, A. von Eckardstein and T. Hornemann*
"Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway"
J. Lipid Res. 2017, 58, 60-71.


J. Sosna, S. Philipp, J. Fuchslocher Chico, C. Saggau, J. Fritsch, A. Föll, J. Plenge, C. Arenz, T. Pinkert, H. Kalthoff, A. Trauzold, I. Schmitz, S. Schütze, D. Adam
"Differences and similarities in TRAIL- and TNF-mediated necroptotic signaling in cancer cells"
Mol. Cell Biol. 2016, 36 2626-44..

R. Steiner*, E.M. Saied*, A. Othman, C. Arenz, A.T. Maccarone, B.L.J. Poad, S.J. Blanksby, A. von Eckardstein, T. Horneman*
"Elucidating the chemical structure of native 1-deoxysphingosine"
J. Lipid Res. 2016, 57, 1194-1203.

T. Kirkegaard, J. Gray, D.A. Priestman, K.-L. Wallom, J. Atkins, O.D. Olsen, A. Klein, S. Drndarski, L. Ingemann, C. Bornæs, S.H. Jørgensen, I. Williams, A. Hinsby, C. Arenz, D. Begley, M. Jäättelä, F.M. Platt
"Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses"
Science Transl Med 2016, 8, 355RA118.

B.F. Straub et al. "Trendbericht Organische Chemie 2015"
Nachr Chem 2016, 63, 255-294.

M. Hesse and C. Arenz*
"A rapid and versatile assay of Ago2-mediated cleavage using branched rolling circle amplification"
ChemBioChem 2016, 17, 304-307.

E. M. Saied, C. Arenz*
"Inhibitors of Ceramidases"
Chem Phys Lipids 2016, 19760-68.


E. M. Saied, S. Banhart, S. E. Bürkle, D. Heuer, C. Arenz*
"A Series of Ceramide Analogues Modified at the 1-Position With Potent Activity Against the Intracellular Growth of Chlamydia trachomatis"
Future Med Chem 2015, 7, 1971-1980.

C. Tabeling, H. Yu, L. Wang, H. Ranke, N. M. Goldenberg, D. Zabini, E. Noe, A. Krauszman, B. Gutbier, J. Yin, M. Schaefer, C. Arenz, A. C. Hocke, N. Suttorp, R. L. Proia, M. Witzenrath, W. M. Kuebler*
"CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction"
Proc Natl Acad Sci USA 2015, 112, E1614–E1623.

B.F. Straub et al. "Trendbericht Organische Chemie 2014"
Nachr Chem 2015, 62, 264-301.

N. Ogorodnikova and C. Arenz*
"miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650"
Expert Opin Ther Pat. 2015, 25, 723-727


M. Hesse and C. Arenz*
"miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650"
Expert Opin Ther Pat. 2014, 11, 1271-6

S. Banhart, E. M. Saied, A. Martini, S. Koch, L. Aeberhard, K. Madela, C. Arenz, and D. Heuer*
"Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization"
Antimicrob. Agents Chemother. 2014, 58, 5537-5546

E. M. Saied, C. Arenz*
"Small Molecule Inhibitors of Ceramidases"
Cell Phys Biochem 2014, 34, 197-212.

E. M. Saied, S. Diederich, C. Arenz*
"Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives"
Chem Asian J 2014, 9 2092–2094.

S. Voigt, S. Philipp, P. Davarnia, S. Winoto-Morbach, C. Röder, C. Arenz, A. Trauzold, D. Kabelitz, S. Schütze, H. Kalthoff and D. Adam*
"TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells"
BMC Cancer 2014, 14, 74.

G. Schwarzmann*, C. Arenz*, K. Sandhoff*
"Labeled Chemical Biology Tools for Investigating Sphingolipid Metabolism, Trafficking and Interaction with Lipids and Proteins"
BBA - Molecular and Cell Biology of Lipids 2014, 1841, 1161-1173.

S. Bräse et al. "Trendbericht Organische Chemie 2013"
Nachr Chem 2014, 62, 264-301.

M. Hesse, C. Arenz*
"Micro RNA maturation and human disease (Review)"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 11-25.

M. Hesse, B.P. Davies, C. Arenz*
"Assaying Dicer-mediated miRNA maturation by means of fluorescent substrates"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 95-102.

S. Neubacher, C. Arenz*
"Assaying micro RNA Maturation Using Unmodified pre-miRNA"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 109-119.


N. H. T. Petersen, O. D. Olsen, L. Groth-Pedersen, A. M. Ellegaard, M. Bilgin, S. Redmer, M. S. Ostenfeld, D. Ulanet, T. H. Dovmark,
A. Lønborg, S. D. Vindeløv, D. Hanahan, C. Arenz, C. S. Ejsing, T. Kirkegaard, M. Rhode, J. Nylandsted, M. Jäättelä*
"Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase"
Cancer Cell 2013, 24, 379-393.

A. A. Bastian, E. M. Warszawik, P. Panduru, C. Arenz and A. Herrmann*
"Regioselective Diazo-Transfer Reaction at the C3-Position of the 2-Desoxystreptamine Ring of Neamine Antibiotics"
Chem Eur J 2013, 19, 9151–9154.

K. P. Bhabak, A. Hauser, S. Redmer, S. Banhart, D. Heuer, C. Arenz*
"Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activities"
ChemBioChem 2013, 14, 1049-1052.

C. Schöniger, C. Arenz*
"Perspectives in targeting miRNA function"
Bioorg. Med. Chem. 2013, 21,6115-6118

C. M. Dojahn, M. Hesse, C. Arenz*
"Chemo-enzymatic Approach to specifically click-modified RNA"
Chem. Commun. 2013, 49, 3128-3130

S. Bräse et al. "Trendbericht Organische Chemie 2012"
Nachr Chem 2013, 61, 265-297.

K. P. Bhabak, C. Arenz*
"Novel Drugs Targeting Sphingolipid Metabolism" (Book Chapter)
Handb Exp Pharmacol. (Editors: E. Gulbins, I Petrache) 2013, 215, 187-196.

K. P. Bhabak, B. Kleuser, A. Huwiler, C. Arenz*
"Effective Inhibition of Acid and Neutral Ceramidases by Novel B-13 and LCL-464 analogues"
Bioorg. Med. Chem. 2013, 21, 874-882.


K. P. Bhabak, C. Arenz*
"Novel Amide- and Sulfonamide-based Aromatic Ethanolamines: Effects of Various Substituents on the Inhibition of Acid and Neutral Ceramidases"
Bioorg. Med. Chem. 2012, 20, 6162-6170

K. P. Bhabak, D. Proksch, S. Redmer, C. Arenz*
"Novel Fluorescent Ceramide Derivatives for Probing Ceramidase Substrate Specificity"
Bioorg. Med. Chem. 2012, 20, 6154-6161

S. Bräse et al. "Trendbericht Organische Chemie 2011"
Nachr Chem 2012, 60, 265-299.

R. Samapati, Y. Yang, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, S. Wu, C. Stoerger, V. Flockerzi, S. Uhlig*, W.M. Kübler*
"Regulation of lung vascular permeability by acid sphingomyelinase dependent activation of TRPC6"
Am J Respir Crit Care Med. 2012, 185, 160-170

M. Sand*, M. Skrygan, C. Arenz, D. Georgas, T. Gambichler, D. Sand, P. Altmeyer, F.G. Bechara
"Expression Levels of the microRNA Maturing Microprocessor Complex Component DGCR8 and the RNA-Induced Silencing Complex (RISC)
Components Argonaute-1, Argonaute-2, PACT, TARBP1, and TARBP2 in Epithelial Skin Cancer"
Mol. Carcinog. 2011, 51, 916-922


S. Neubacher, C.M. Dojahn, C. Arenz*
"A Rapid Assay for miRNA Maturation using Unmodified pre-miRNA"
ChemBioChem. 2011, 12, 2302-2305

S. Bräse et al. "Trendbericht Organische Chemie 2010"
Nachr Chem 2011, 59, 254-283.

D. Proksch, J.J. Klein, C. Arenz*
"Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues"
J. Lipids 2011, doi:10.1155/2011/971618 PDF


S. Wetzel, W. Wilk, S. Chamma, B. Sperl, A.G. Roth, A. Yektaoglu, S. Renner, T. Berg, C. Arenz, A. Giannis, T.I. Oprea, D. Rauh, M. Kaiser, and H. Waldmann*
"A Scaffold Tree Merging Strategy for Prospective Bioactivity Annotation of gamma-pyrones"
Angew. Chem. 2010, 122, 3748-3752

S. Bräse et al. "Trendbericht Organische Chemie 2009"
Nachr Chem 2010, 58, 267-299

C. Arenz*
"Small Molecule Inhibitors of Acid Sphingomyelinase"
Cell Phys Biochem 2010, 26, 1-8

T. Kirkegaard, A. G. Roth, N. H. T. Petersen, A. K. Mahalka, O. D. Olsen, I. Moilanen, A. Zylicz, J. Knudsen, K. Sandhoff, C. Arenz, P. K. J. Kinnunen, J. Nylandsted, M. Jäättelä*
"Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology"
Nature 2010, 463, 549-554

A. G. Roth, S. Redmer and C. Arenz*
"Carbohydrate-Derived Inhibitors of Acid Sphingomyelinase"
Bioorg. Med. Chem. 2010, 18, 939-944.


Anke G. Roth, S. Redmer, C. Arenz*
"Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues"
ChemBioChem. 2009, 2367-2374.

A. G. Roth, D. Drescher, Y. Yang, S. Redmer, S. Uhlig, C. Arenz*
"Potente und selektive Inhibition der sauren Sphingomyelinase durch Bisphosphonate"
Angew. Chem. 2009, 121, 7697-7700.

S. Neubacher, C. Arenz*
"Rolling Circle Amplification: Unshared Advantages in miRNA Detection"
ChemBioChem. 2009, 10 (8), 1289-1291.

C. M. Klemm, A. Berthelmann, S. Neubacher, C. Arenz*
"Short and Efficient Synthesis of Alkyne-Modified Aminoglycoside Building Blocks"
Eur. J. Org. Chem. 2009, 17, 2788-2794.


B. P. Davies, C. Arenz*
"A Fluorescence Probe for Assaying micro RNA maturation"
Bioorg. Med. Chem. 2008, 16, 49-55.


J. O. Babalola, M. Wendeler, B. Breiden, C. Arenz, G. Schwarzmann, S. Locatelli-Hoops, K. Sandhoff*
"Development of an Assay for the Intermembrane Transfer of Cholesterol by Niemann-Pick C2 Protein"
Biol. Chem. 2007, 388, 617-626.

C. Arenz, O. Seitz "DNA Made of Purines Only" (Preview)
Chem. Biol. 2007, 14, 467-469.


C. Arenz "Peptidnukleinsäuren in der Biomedizin" (Trendbericht 2005)
Nachr. Chem. 2006, 54, 270-273.

C. Arenz "MicroRNAs - zukünftige Wirkstoff-Targets?" (Highlight)
Angew. Chem. 2006, 118, 5170-5172.

B. P. Davies, C. Arenz "Ein homogener Assay der microRNA-Reifung"
Angew. Chem. 2006, 118, 5676-5679.




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